Lineage specificity of gene expression patterns
نویسندگان
چکیده
منابع مشابه
Lineage specificity of gene expression patterns.
The hematopoietic system offers many advantages as a model for understanding general aspects of lineage choice and specification. Using oligonucleotide microarrays, we compared gene expression patterns of multiple purified hematopoietic cell populations, including neutrophils, monocytes, macrophages, resting, centrocytic, and centroblastic B lymphocytes, dendritic cells, and hematopoietic stem ...
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We present here a heuristic method toward predicting the expression specificity in the transcriptional process, which is known to be regulated in large part by promoter sequences, by observing the appearance of conserved sequence patterns in a group of known promoters, such as for housekeeping or tissue-specific genes. Statistically conserved patterns were automatically extracted from a set of ...
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Haemopoietic stem cells have the potential to activate up to eight distinct cell lineage specific genetic programmes [1]. The mechanisms of cell lineage choice or commitment are fundamental to developmental biology in general and are beginning to be unravelled at least in invertebrates (e.g., Drosophila, Nematodes, slime moulds). Transacting DNA binding proteins that directly or indirectly regu...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0401136101